Leuphasyl 200mg (Pentapeptide-18)

Leuphasyl 200mg is an enkephalin-like cosmetic pentapeptide, and Raw Amino sells it as freeze-dried powder in a 200mg vial. It’s sold for laboratory research only.

What is Leuphasyl (pentapeptide-18)?

Pentapeptide-18 is a five-amino-acid peptide (Tyr-D-Ala-Gly-Phe-Leu) modeled on the enkephalins, the body’s own short opioid peptides. Lipotec sells it under the name Leuphasyl.

It was designed to calm the nerve signal that makes facial muscles contract, and it’s usually studied next to argireline because the two work at different steps of that signal.

Buy Leuphasyl 200mg online with free shipping

Raw Amino keeps Leuphasyl 200mg in stock at $212. When you order, you get:

• Shipping is free on all orders, worldwide
• Code firstrawamino$$ takes 10% off your first order
• Pay with crypto and get 15% off at checkout
• Currently in stock; every vial ships sealed and labelled

How Leuphasyl works

Enkephalins bind receptors on nerve endings and make the neuron less excitable. Pentapeptide-18 copies that action, so less acetylcholine is released toward the muscle.

Argireline works further down the line by interfering with the SNARE complex that packages acetylcholine for release. Because the two act at separate points, researchers combine them to look for additive effects.

Leuphasyl 200mg product details

• Compound: Leuphasyl (pentapeptide-18)
• Molecular formula: C29H39N5O7
• Molar mass: 569.7 g/mol
• Sequence: Tyr-D-Ala-Gly-Phe-Leu
• Amount: 200mg per vial
• Form: freeze-dried (lyophilized) powder in a sealed glass vial
• SKU: RA-LEUPHASYL-200MG
• Stock: in stock
• Use: laboratory research only

Published studies on Leuphasyl

The supplier reported that a cream with pentapeptide-18 reduced the depth of expression lines over a month, and that combining it with acetyl hexapeptide-3 gave a larger drop than either peptide alone.

These are manufacturer studies. Peer-reviewed independent trials are limited, so most labs use it as a mechanism comparator in nerve and muscle cell models.

To read the original papers, start with this PubMed search for Pentapeptide-18 at the US National Library of Medicine.

Leuphasyl vs related compounds

Leuphasyl copies enkephalin and calms the nerve before it fires. The compounds it’s usually compared with:

• Vialox blocks the muscle acetylcholine receptor, a curare-like action
• SNAP-8 is an eight-amino-acid cosmetic peptide studied for expression lines
• Argireline limits acetylcholine release by acting on the SNARE complex in nerve endings
• Syn-AKE mimics a snake venom peptide and blocks the acetylcholine receptor on muscle

These are the expression-line peptides. They all damp the nerve-to-muscle signal, but at different points: before release, during release or at the muscle receptor. See them side by side on our skin and cosmetic peptides page.

What is printed on the Leuphasyl 200mg vial

Each vial carries the Raw Amino logo, the compound name and a purple Research use only band, with the amount (200mg) shown on the label. Check those details when the box arrives and keep the vial sealed until you need it.

Don’t judge the fill by eye. A few milligrams of freeze-dried peptide takes up almost no room, and it can break into flakes on the way to you without any effect on the amount.

If your protocol requires in-house confirmation, set a little material aside from the first vial for your own analysis before the study starts.

Reconstituting Leuphasyl 200mg

Work out concentration by dividing what’s in the vial by the water you add. For example:

• 200mg vial plus 5mL of water: 40mg per mL
• 200mg vial plus 10mL of water: 20mg per mL

Most labs use sterile bacteriostatic water. Let the sealed vial come to room temperature, then run the water slowly down the inside of the glass and roll the vial gently until it’s clear. Shaking makes foam and can damage the peptide, so don’t.

Write the concentration and the date on the label as soon as you’ve mixed it.

Storing Leuphasyl 200mg

For long-term storage, freeze sealed Leuphasyl 200mg at -20°C in the dark. Freeze-dried peptide is stable enough to travel at room temperature for several days.

Mixed solution goes in the fridge between 2 and 8°C and should be used within roughly a month. Keep the other vials sealed and frozen until you need them.

Related skin and cosmetic peptides

• Matrixyl 200mg (Palmitoyl Pentapeptide-4): a signal peptide
• Argireline 200mg (Acetyl Hexapeptide-3): a hexapeptide
• GHK Basic 50mg: a copper-free tripeptide
• Nonapeptide-1 200mg: an MC1R antagonist peptide
• AHK-Cu 200mg: a copper peptide

Compare more options in the skin and cosmetic peptides range or go back to the Raw Amino shop.

Common questions about Leuphasyl 200mg

How much is in the Leuphasyl 200mg vial?

200mg of freeze-dried Leuphasyl. The amount is printed on the label.

Do you ship internationally?

Yes. Shipping is free on every order, worldwide.

Is there a discount code?

Yes. New customers can use firstrawamino$$ for 10% off, and crypto payments get 15% off at checkout.

What do I mix Leuphasyl 200mg with?

Sterile bacteriostatic water. The mixing chart above shows the concentration you get from each volume.

How should I store Leuphasyl 200mg?

Freeze sealed vials at -20°C. Once mixed, keep it at 2 to 8°C in the fridge and use it within about four weeks.

Order Leuphasyl 200mg from Raw Amino

Leuphasyl 200mg is in stock at $212. Add it to your cart, enter firstrawamino$$ for 10% off your first order, and it ships free.

Need more for the same project? Look through the skin and cosmetic peptides.

Raw Amino sells this product for laboratory research only. It isn’t for human or veterinary use, and these statements haven’t been evaluated by the FDA.